منابع مشابه
Interleukin-6 and cardiovascular diseases.
Inflammatory cytokines are important for both cardiovascular scientists and practicing clinicians. Interleukin-6 (IL-6) has been emphasized by reports of elevated circulating as well as intracardiac IL-6 levels in patients with congestive heart failure (CHF). IL-6 may contribute to the progression of myocardial damage and dysfunction in chronic heart failure syndrome resulting from different ca...
متن کاملInterleukin-6 and rheumatic diseases
IL-6 is a pleiotropic cytokine involved in both the initiation and the maintenance of the inflammatory and immunologic responses in certain autoimmune diseases. Blocking of these two complementary functions of IL-6 may confer additive, or even unique, benefits to the patient. The levels of both IL-6 and its soluble receptor (sIL-6Ralpha) are elevated to various degrees in many rheumatic disease...
متن کاملInterleukin-6; pathogenesis and treatment of autoimmune inflammatory diseases
Toshio Tanaka1, 2), Masashi Narazaki3), Kazuya Masuda4) and Tadamitsu Kishimoto4,*) 1)Department of Clinical Application of Biologics, Osaka University Graduate School of Medicine, Osaka University, Osaka, Japan 2)Department of Immunopathology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan 3)Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka Univ...
متن کاملInterleukin 6 in autoimmune and inflammatory diseases: a personal memoir
In this review, the author discusses the research that led to the identification and characterization of interleukin 6 (IL-6), including his own experience isolating IL-6, and the roles this cytokine has on autoimmune and inflammatory diseases. The cDNAs encoding B-cell stimulatory factor 2 (BSF-2), interferon (IFN)-beta2 and a 26-kDa protein were independently cloned in 1986, which in turn led...
متن کاملRole of Interleukin-37 in Inflammatory and Autoimmune Diseases
Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...
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ژورنال
عنوان ژورنال: Japanese Heart Journal
سال: 2004
ISSN: 0021-4868,1348-673X
DOI: 10.1536/jhj.45.183